Kat L - email@example.com
I fractured my sacrum & T10 vertebrae in a construction accident on May 11 2002. The sacral fracture was an unusual "U" shaped compression fracture. I was on narcotics for 13 days, then the doc started me on Neurontin, 100 mg. I also take 2 Ibuprofen with each dose, because of other "related pain" -- coccyx, spinal, & buttock pain. This does a fair job, I would say.
I'm wondering how long I can keep up this regimen? I read on the Pfizer website about all the side effects during trials. Death and pancreatic tumors were listed. I only have drowsiness and just the feeling of being "dense". There is an extract from it below.
Does anyone have other medications that have worked for them, with similar bone fractures & coccyx pain/burning?
From the Pfizer website, discussing possible risks of Neurontin (Gabapentin):
Carcinogenesis, Mutagenesis, Impairment of Fertility
Gabapentin was given in the diet to mice at 200, 600, and 2000 mg/kg/day and to rats at 250, 1000, and 2000 mg/kg/day for 2 years. A statistically significant increase in the incidence of pancreatic acinar cell adenomas and carcinomas was found in male rats receiving the high dose; the no-effect dose for the occurrence of carcinomas was 1000 mg/kg/day. Peak plasma concentrations of gabapentin in rats receiving the high dose of 2000 mg/kg were 10 times higher than plasma concentrations in humans receiving 3600 mg per day, and in rats receiving 1000 mg/kg/day peak plasma concentrations were 6.5 times higher than in humans receiving 3600 mg/day. The pancreatic acinar cell carcinomas did not affect survival, did not metastasize and were not locally invasive. The relevance of this finding to carcinogenic risk in humans is unclear.
Note from Jon Miles:
No drug is without risk, and most drugs have possible serious side-effects listed. But such effects are very rarely seen in practice, or the drug companies would not be allowed to sell the drugs. In this case the pancreatic cancers were found in male rats given very high doses of the drug, but not in female rats or in mice.